World Congress on Advances in Brain Injury, Disorders and Therapeutics October 21-22, 2019 | Tokyo, Japan

A large number of clinical data surveys have shown that women are more likely to be depressed than men. Chaihu-Shugan-San (CSS) is an classical prescriptions for treating ‘liver depression and qi stagnation’. We aim to observe the effect of CSS and its Absorbed Bioactive Compounds (ABCs) on depressive behaviors, the blood oxygen level in the brain region depends on the influence of 7.0 T functional magnetic resonance imaging (BOLD-fMRI) and depressant-related biochemical indicators of acute (or chronic) stress female rats. It is interesting to note that the female rats were more easily be depressed when suffered chronic unpredictable mild stress compared with male rats (p<0.001) while female rats show stronger resistance to stress during acute stress. After giving CSS (30 g/kg), the immobility time of forced swimming test was shorter than vehicle group and the movement distance was farther (p<0.001). At the same time, 10 ABCs exerted anti-depressive effect similar to its parent prescription Chaihu-Shugan-San. Then we used the BOLD-fMRI technology, visually reflected the reducing of blood oxygen levels in hippocampus and thalamus in female rats after stress and the increase after giving CSS (Reho-0.005-50).This technology had great potential in the pathological localization of depression, the monitoring of depression status, the efficacy of antidepressant therapy and prognosis. Last, ELISA results shown the levels of CRH/ACTH were higher than control group while E2, DA, NE, 5-HT in serum and the BDNF and TrkB in and hippocampus were obvious decreased (p<0.001). CSS and 10 ABCs could improve depressive symptoms by HPA axis/HPG axis/monoamine neurotransmitter and many other pathways.

This research shown the multiple targets of CSS on female rats after suffering acute forced swimming which may help to explain the work way of TCM.

In the previous experiment, we tested the hypothesis that a simple, rapid and sensitive Ultra-Performance Liquid Chromatography (UPLC) method has been developed for the simultaneous determination of eight constituents including

narirutin, naringin, hesperidin, neoheperidin, Merancin Hydrate (MH), nobiletin, honokiol and magnolol in Zhiqiao-Houpu decoction and determination of MH in rat plasma following the oral administration of Zhiqiao-Houpu decoction (20 g/kg).We have confirmed that MH has good effects on antidepressant (P<0.010, prokinetic (P<0.01) and related anti-inflammation (P<0.010) and anti-oxidation (P<0.01) in vivo. Then we sequenced the intestinal flora in the V4 region of caecum contents in rats 24 hours after FST

She was born as a high functioning autistic in a communist country within a family and society ignorant to the spectrum. She has learnt to use her special interest in people as a super-power to shift the paradigm and integrate radically new concepts and insights about the autistic world into the not-autistic frame of reference. At present, she is a certified SEN tutor, an author, consultant and inspirational speaker on autism. All her years of experience, combined with being autistic herself, give her a point of view and a set of perceptions very different from the ordinary which makes her input original and insightful.

While there are many assessments, support systems and practices in place established over the years for autistic children they have been focused on the child exclusively. An admirable campaign on public education has been launched to help for some adjustments and exceptions to be made at schools and promote the settling of a culture of more acceptance. Still, it does not require people to take personal responsibility which still lies with the autistic person. I propose that society’s mindset need to change and urgently. Parents need fresh eyes, and a new perspective that can add another piece of the impossible puzzle they are solving every day, but solutions come naturally only when the questions are clear. An autism therapy is only possible if it’s applied to the collective. We need to understand that autism is not cases of isolated, unfortunate incidents but a collective phenomenon.

Tahoura Nedaee is an Iranian inventor. Her first invention “human balance control system for middle ear disease” earned her Gold Medal of ITE International Invention Show, London, August, 2019, Gold Medal of 43th International Invention Show, Croatia, November, 2018 and Outstanding Innovation Award by the Commission of Higher Education, Thailand, November, 2018

One of the diseases that many people are suffering from is ataxia or disability to maintain balance. A lot of elderly and weak people are suffering from disability to maintain balance, due to decreased sensory and motor ability caused by degeneration. It may cause them to fall down and lead to more serious damages, even death. Moreover, falling down, increases the medical expenses incurred on the health system, due to the serious consequences. So it seems necessary to prevent these consequences. For this purpose, a system was designed and built that by controlling the middle ear, which plays a special role in balance, helps to prevent falls and allows the patients to maintain balance. Required feedbacks to control static and motor balance include sense of vision, vestibular system, inner ear and somatosensory system. Different studies and different solutions have been performed to maintain balance. Such as foot arch supporters, textured or bumpy surfaces, special shoes,etc.But this system’s process, designed to maintain body balance in people with balance control disabilities, is done by affecting the middle ear. After detecting the patient’s head position by this system, it will send messages to the brain. By detecting the messages by the brain, the patient will be able to control his or her balance. Previously used balance control equipment and methods can be replaced by this system.

Seda Maeresera holds a Master’s degree in Public Health from the University of Roehampton, London, UK, as well as a Bachelor’s degree in Occupational Therapy from the University of Zimbabwe. He is currently working in the traumatic brain injury units at Sultan Bin Abdulaziz Hospital in Saudi Arabia.

The study was qualitative in nature. 12 participants from each of the professions of social workers, occupational therapists, nurses and doctors were recruited for the study using purposive sampling. The subjects were from Parirenyatwa Hospital and St. Giles Rehabilitation Centre in Harare, Zimbabwe. The instrument was a 7 question semi-structured interview administered either face to face or via telephone calls. Data were analyzed using thematic analysis.